UMMC Icare

Popular Heartburn Medications Linked to Higher Stroke Risk

“So, if you have heartburn very rarely — especially people who have heartburn associated with certain foods — they could take antacids.”
Antacids provide quick relief, but only for a short amount of time, said Badger-Plange, and consumers should pay close attention to the ingredients on the label. What are the alternatives? “This study further questions the cardiovascular safety of these drugs.”
For years, doctors have questioned whether too many people are taking heartburn drugs. If you’re pregnant, you should avoid sodium bicarbonate and magnesium trisilicate. “Patient safety is a top priority … and we continuously monitor the safety of all our medicines and collaborate with regulatory agencies to ensure this information is reflected in the respective prescribing information,” a spokesman said in an email to CNN. “We wanted to see if PPIs also posed a risk for ischemic stroke, especially given their increasing use in the general population.”
Most serious warning yet
The research was conducted in Denmark among a quarter-million patients who suffered from stomach pain and indigestion, and were taking one of four PPIs: Prilosec, Protonix, Prevacid or Nexium. Ischemic strokes are the most common type of stroke, according to the Centers for Disease Control and Prevention. For longer-lasting relief, H2 antagonist medications (also called H2 blockers) are also an option, but they can take a few hours to kick in. “So, if you have a lot of medications, you probably want to check with your pharmacist at the counter to make sure it’s OK to take those medications.”
As always, you should talk to your doctor before starting or stopping any medication — prescribed or over the counter. Prilosec OTC has the longest history of safe and effective consumer use of any [over the counter] PPI.”
Takeda, the maker of Prevacid, said it could not comment on the results and conclusions of the study until the full data is published for review. At the highest doses, they found that stroke risk increased 33% for Prilosec and Prevacid patients, 50% for Nexium patients and 79% for Protonix patients. “At one time, PPIs were thought to be safe, without major side effects,” Sehested said. Stomach acid seems to play a role in killing off both good and bad bacteria in our gut. In an email to CNN, P&G, the company that makes Prilosec, said the drug is an “FDA approved, safe and effective remedy to relieve frequent heartburn symptoms. “Antacids usually would help if you have less than one incident a week,” Badger-Plange said. If your doctor determines that you do need pills for your problem, pharmacist NaaDede Badger-Plange suggests starting with an antacid, such as Tums, Rolaids or Maalox. They occur when a blood clot cuts off blood flow to the brain. Thomas Sehested, the study’s lead author and a researcher at the Danish Heart Foundation. “Consumers need to ask their doctors, ‘Why am I taking this? At the lowest doses, the authors found either no or minimal increased risk of stroke. “PPIs have been associated with unhealthy vascular function, including heart attacks, kidney disease and dementia,” said Dr. A pair of 2010 studies found that PPIs were associated with an increased risk of a serious bacterial infection. For years, Katz has been worried that PPIs “reinforce the idea that the solution to behavioral health issues is to take a pill, and that’s just not how we’re going to get healthier,” he said in 2010. When someone is taking PPIs, their amount of stomach acid is reduced, and it creates an environment in which bacteria can flourish. “As a culture, we tend to want a pill to deal with our problems, when a lot of people could reduce their heartburn by eating smaller meals, drinking less alcohol or not smoking,” Dr. Patients with kidney disease should avoid antacids that contain aluminum. Overall stroke risk increased 21% among patients who were taking a PPI, according to the study. Michael Katz, who wrote an editorial accompanying the studies, told CNN in 2010. Pfizer, the maker of Protonix, did not respond to CNN’s request for comment. In April, another study published in the Journal of the American Society of Nephrology found that patients who took PPIs had a 96% increased risk of kidney failure and a 28% increased risk of kidney disease, compared with those who were prescribed alternative medications. Do I still need this? Millions of Americans take proton pump inhibitors to treat acid reflux and heartburn. Medical professionals estimate that the majority of people who suffer from acid reflux or heartburn could drastically or completely reduce their discomfort by making a few lifestyle changes: quit smoking, lose weight and cut back on spicy and fatty foods. Do I have an alternative?’ “ AstraZeneca, the maker of Nexium, said, “Patient safety is an important priority … and we believe all of our PPI medicines are generally safe and effective when used in accordance with the label.” A spokeswoman said the company was not consulted during the research, so it could not comment on the data. But according to preliminary research presented today at an American Heart Association conference in New Orleans, these medications may also increase the risk of ischemic stroke. “One thing to keep in mind is, certain products that are in the H2 receptor antagonist class have drug interactions,” Badger-Plange said. Sometimes, solving one problem only creates another. Known as PPIs, they are among the most prescribed drugs in the United States and are widely available over the counter.